Articles

Does the Value per Statistical Life vary with age or baseline health? Evidence from a compensating wage study in France.
Auteurs : Daniel Herrera-Araujo and Lise Rochaix

Abstract : We study the incidence of social security contributions (SSCs) in France relying on the strategy developed by Alvaredo et al. (De Econ, 2017. doi:10.1007/s10645-017-9294-7). This strategy infers the incidence of SSCSs from the discontinuities in earnings… Lire la suite


The Meliorist Project in health economics
Auteurs : David Bishai et Lise Rochaix

Abstract : Health economics is driven by its applications to improve the health and well‐being of individuals, people, and places. Health economists are intellectual descendants of 19th century meliorists (Bentham & Bowring, 1843) who believed that: (1) coordinated human… Lire la suite


Generating comparative evidence on new drugs and devices before approval
Auteurs : Huseyin Naci, Maximilian Salcher-Konrad, Aaron S Kesselheim, Beate Wieseler, Lise Rochaix, Rita F Redberg, Georgia Salanti, Emily Jackson, Sarah Garner, T Scott Stroup, Andrea Cipriani

Abstract : Fewer than half of new drugs have data on their comparative benefits and harms against existing treatment options at the time of regulatory approval in Europe and the USA. Even when active-comparator trials exist, they might not produce meaningful data to inform decisions… Lire la suite


Effectiveness and efficiency of teleimaging in the transplantation process: a mixed method protocol
Auteurs : Kevin Zarca, Jean-Claude K. Dupont, Lorène Jacoud, Julie Bulsei, Olivier Huot, Hélène Logerot & Isabelle Durand-Zaleski

Abstract : The transplantation process usually takes place without transplant teams being able to use imaging data to assess graft quality. The decision of whether to go get the graft or not is therefore limited and suboptimal… Lire la suite


Innovative curative treatment of beta thalassemia: Cost-efficacy analysis of gene therapy versus allogenic hematopoietic stem-cell transplantation.
Auteurs : Séverine Coquerelle, Mariem Ghardallou, Setti Rais, Pierre Taupin, Fabien Touzot, Laure Boquet, Stéphane Blanche, Semir Benaouadi, Thomas Brice, Caroline Tuchmann-Durand, Jean Antoine Ribeil, Elisa Magrin, Etienne Lissillour, Lise Rochaix, Marina Cavazzana, and Isabelle Durand-Zaleski

Abstract : Seventy-five percent of patients with beta thalassemia (β-thalassemia) do not have human leukocyte antigen–matched siblings and until recently had no access to a curative treatment. Gene therapy is a promising treatment that can be proposed to these patients… Lire la suite


(In)-Equality in the Allocation of R&D Resources for Rare Diseases
Auteurs : Setti Raïs Ali et Sandy Tubeuf

Abstract : This paper analyses the allocation of R&D investments within rare diseases and identifies the characteristics of rare diseases that appear to lead R&D resources. Rare diseases affect less than 1 in 2000 citizens… Lire la suite


L’influence des accidents de la route sur les trajectoires professionnelles des personnels en fin de carrière, à partir de la cohorte Gazel
Auteurs : Marc-Antoine Sanchez, Thomas Barnay, Antoine Marsaudon, Lise Rochaix

Abstract : L’objectif de cet article est d’évaluer l’effet des accidents de la route sur les trajectoires professionnelles des employés de court et moyen terme d’EDF-GDF en fin de carrière, à partir de la cohorte Gazel sur la… Lire la suite


Was It Worth Introducing Health Economic Evaluation of Innovative Drugs in the French Regulatory Setting? The Case of New Hepatitis C Drugs
Auteurs : Valérie Clément et Véronique Raimond

Abstract : This paper constitutes the first attempt to draw lessons from the recent uptake of health economic evaluation of innovative drugs in the French regulatory framework… Lire la suite


Impact d’un choc de santé sur les modes de vie, exploitation de la cohorte Gazel
Auteurs : Antoine Marsaudon et Lise Rochaix

Abstract : This paper investigates the relationship between an acute health shock, namely the first onset of an accident requiring medical care, and smoking, using rich panel data from a large French cohort of electricity… Lire la suite


Does global drug innovation correspond to burden of disease? The neglected diseases in developed and developing countries
Auteurs : Eliana Barrenho, Marisa Miraldo et Peter C. Smith

Abstract : Although it is commonly argued that there is a mismatch between drug innovation and disease burden, there is little evidence on the magnitude and direction of such disparities. In this paper, we measure inequality in innovation… Lire la suite


Pathways to sustainability: A fuzzy-set qualitative comparative analysis of rural water supply programs
Auteurs : Sara J. Marksa, Emily Kumpel, Jean Guo, Jamie Bartram, Jennifer Davis

Abstract : Despite recent progress extending access to drinking water supplies globally, ensuring long-term functionality of rural water infrastructure remains challenging. Past research on rural water project outcomes has used two principal approaches… Lire la suite 


Parents’ and children’s comprehension and decision in early phase oncology trial in pediatric: a prospective study
Auteurs : Agathe Béranger, Naïm Bouazza, Amélie de Haut de Sigy, Anne-Charlotte Foubert-Wenc, Dominique Davous, Isabelle Aerts, Birgit Geoerger, Anne Auvrignon, Benoît Brethon, Pierre Leblond, Nadège Corradini, Nicolas André, Hélène Martinez, Jean-Claude K Dupont , François Doz, Hélène Chappuy

Abstract : Objective To analyse parents’ and children’s understanding of consent information and assess their decision-making process in paediatric oncology… Lire la suite


Éthique et économie de la santé : quels enjeux actuels 
Auteurs : Jean-Claude K. Dupont, Clémence Thébaut, Jérôme Wittwer

Abstract : La santé d’une population est le reflet d’arbitrages individuels et de choix collectifs. Les deux sont liés, naturellement, les préférences s’héritent et se construisent facesaux contraintes et les contraintes sont façonnées par les choix collectifs. Notre rôle est d’évaluer l’impact… Lire la suite


Cost-effectiveness of interventions based on physical activity in the treatment of chronic conditions: a systematic literature review
Auteurs : Marlène Guillon, Lise Rochaix et Jean-Claude K. Dupont

Abstract : The aim of this study is to review evidence on the cost-effectiveness of exercise-based interventions in the treatment of chronic conditions a decade after the publication of Roine et al… Lire la suite 


The effect of group purchasing on prices hospitals pay for medicines
Auteurs : Léa Toulemon

Abstract : I estimate the impact of group purchasing on medicine prices in French hospitals, taking advantage of the entry of hospitals into regional purchasing groups between 2009 and 2014. Based on a new database providing the average annual prices paid for all innovative and high‐priced medicines in public hospitals… Lire la suite 


Enrollment in early‐phase clinical trials in pediatric oncology: The experience at Institut Curie
Auteurs : Aurore Surun, Marie‐Églantine Dujaric, Isabelle Aerts, Daniel Orbach, Irène Jiménez, Hélène Pacquement, Gudrun Schleiermacher, Franck Bourdeaut, Jean Michon, Jean‐Claude K. Dupont, François Doz

Abstract : The European Paediatric Regulation was introduced in 2007 to facilitate access to new medicines for children. Our study explored accessibility of early‐phase trials in pediatric oncology, in line with the European Paediatric Regulation… Lire la suite 


Le prix des médicaments en France: présentation synthétique des évolutions récentes du système français de fixation des prix
Auteurs : Laurie Rachet Jacquet, Léa Toulemon, Véronique Raimond, Albane Degrassat-Théas, Lise Rochaix, Pascal Paubel

Abstract : Cet article présente les différents aspects de la détermination du prix des médicaments remboursables en France. Nous abordons la manière dont les prix des médicaments sont fixés selon… Lire la suite 


Early access schemes and pricing strategies: A case study on temporary authorization for use in France from 1994 to 2016
Auteurs : Setti Raïs Ali, Véronique Raimond, Albane Degrassat-Théas, Laurie Rachet Jacquet, Lise Rochaix, Xiaoyan Lu, Pascal Paubel

Abstract : Early access schemes for pharmaceuticals have been increasingly implemented worldwide with the objective of satisfying unmet medical needs or facilitating market access… Lire la suite 


Prices, patents and access to drugs: Views on equity and efficiency in the global pharmaceutical industry
Auteurs : Quentin Cavalan, Maud Hazan, Irène Hu, Roxane Zighed

Abstract : In this essay about international drug pricing in the global pharmaceutical market, we focus on the issue of access to medicine in developing countries. Acknowledging the essential trade-off between equity and efficiency that characterizes… Lire la suite 


Aider un parent âgé dépendant. Configurations d’aide et interactions dans les fratries en France
Auteurs : Quitterie Roquebert, Roméo Fontaine et Agnès Gramain

Abstract : Avec le vieillissement démographique, la question de la prise en charge des personnes âgées dépendantes devient un enjeu de société majeur. L’État français a développé des politiques en ce sens, mais la famille et les enfants assument également une grande partie… Lire la suite 


Peeling back the onion: Using latent class analysis to uncover heterogeneous responses to stated preference surveys
Auteurs : James K. Hammitt et Daniel Herrera-Araujo

Abstract : We develop validity tests for application to stated-preference estimates of WTP to reduce mortality risk, i.e., value per statistical life (VSL), and apply these to data obtained by surveying a representative sample of French… Lire la suite 


Ethics evaluation revealing decision-maker motives: a case of neonatal screening
Auteurs : Véronique Raimond, Cléa Sambuc et Leslie Pibouleau

Abstract : This paper aims to describe the added value of combining cost-effectiveness and ethical evaluations when the preferences of the decision maker toward cost-effectiveness evaluation outcomes are not known, with the French national neonatal screening of cystic fibrosis (CF) as a case-study… Lire la suite 


Pay less, consume more? The price elasticity of home care for the disabled elderly in France
Auteurs : Quitterie Roquebert,  Marianne Tenand

Abstract : Little is known about the price sensitivity of demand for home care of the disabled elderly. We partially fill this knowledge gap by using administrative data on the beneficiaries of the main French home care subsidy program in a department and exploiting interindividual variation in provider prices. We address the potential… Lire la suite 


Survenue d’un problème de santé : impact sur la consommation de tabac
Auteurs : Antoine Marsaudon et Lise Rochaix

Abstract : Dans cet article, Antoine Marsaudon et Lise Rochaix étudient l’impact d’un « choc de santé », c’est-à-dire la survenue brutale d’un accident ayant entrainé un recours aux soins, sur la consommation hebdomadaire de tabac, à partir de la cohorte Gazel qui permet de suivre… Lire la suite 


Willingness to pay: a novel approach to assessing the impact of dyslexia in adults
Auteurs : Daniel Herrera-Araujo, Bennett A. Shaywitz, John M. Holahan, Karen E. Marchione, Reissa Michaels, Sally E. Shaywitz, James K. Hammitt

Abstract : While much is known about dyslexia in school-age children and adolescents, less is known about its effects on quality of life in adults. Using data from the Connecticut Longitudinal Study, we provide the first estimates of the monetary value of improving reading, speaking, and… Lire la suite 


Les enjeux d’évaluation du numérique dans le soin
Auteurs : Jean-Claude K. Dupont

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The value of disease prevention vs treatment
Auteurs : Christoph M. Rheinberger, Daniel Herrera-Araujo, James K.Hammitt

Abstract : We present an integrated valuation model for diseases that are life-threatening. The model extends the standard one-period value-per-statistical-life model to three health prospects: healthy, ill, and dead. We derive willingness-to-pay values… Lire la suite 


Les liens entre régime politique et lutte contre le VIH/SIDA : le cas du Kenya
Auteurs : Antoine Marsaudon et Josselin Thuilliez

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Folic acid advisories: a public health challenge?
Auteurs : Daniel Herrera-Araujo

Abstract : Neural tube defects are neurological conditions affecting one in 1000 fetuses in France each year. If a fetus is affected, there is a 90% chance that the pregnancy will be terminated. Increasing folic acid intake to 400μg per day 2months… Lire la suite 


Ethical issues of clinical trials in paediatric oncology: A systematic review over 10 year developments
Auteurs : François Doz, Jean-Claude K. Dupont, Kathy Pritchard-Jones

Abstract : A state-of-the art approach to the debates on ethical issues is key in order to gain guidance on research practices involving sick children and adolescents, as well as to identify research avenues in which it might be… Lire la suite 


L’évaluation économique des produits de santé innovants : quelle interpretation pour quel usage ?
Auteurs : Véronique Raimond, Fabienne Midy, Clémence Thébaut, Catherine Rumeau-Pichon

Abstract : La loi de financement de la sécurité sociale (LFSS) pour 2012 a introduit le critère d’efficience dans la détermination du prix des produits de santé innovants. La mise en œuvre de cette disposition par la Haute Autorité de santé (HAS) et le Comité économique des produits de santé (CEPS)… Lire la suite 


Le développement de nouveaux médicaments en oncologie pédiatrique (aspects éthiques et industriels)
Auteurs : Patricia Blanc, François Doz, Jean-Claude K. Dupont

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